Photo Courtesy of NASA
Microcide, Inc. is Affiliate Partner NASA FTCSC
PRO-SAN Eco-Friendly Antibacterial Products for Home and Commercial
About Us
Microcide®, Inc. is a biotechnology company in Michigan, founded by John A Lopes, Ph.D. and Rose J Lopes in 1990 for research and development of alternative safe and non-toxic eco-friendly biodegradable microbicidal agents. The company has developed a broad platform of basic scientific technology to produce safe and effective multifunctional, broad spectrum and faster acting alternative products that can replace commonly used hazardous chlorine, quaternary ammonium compounds, aldehydes, peroxides and other toxic or oxidizing microbicidal agents. Microcide® products are certified by the USDA BIO-Preferred for BIO-BASED sustainable ingredient contents.
A member of the Michigan Minority Supplier Development Council, Microcide® US made products utilize an innovative and yet paradoxical approach by using food grade ingredients to kill microbes on animate and inanimate surfaces such as fresh produce, sea food, food contact surfaces, as well as on skin and mucous membranes by eliminating the use of unsafe or toxic microbicidal products.
Our innovation was recognized by the awards of two national competitive SBIR research grants one from the NIH and the other from the NASA. Microcide® was also nominated by the EPA for the Presidential Green Chemistry Award. Dr. Lopes has received more than 10 US and Canadian patents for its technology and has received the Albert Nelson Marquis Lifetime Achievement Award. Dr. Lopes is author of multiple peer reviewed scientific publications and book editions including chapters in Disinfection, Sterilization and Preservation.
Our main product lines include registered trademarks of PRO-SAN® produce wash and surface sanitizer, PRO-SAN® Antifungals for crops, and SILKY SOFT® Alcohol free hand and body wash effective against a myriad of spoilage and pathogenic microbes including coronavirus, H1N1 flu, antibiotic resistant superbugs, viruses and fungi. A number of products are registered with the US EPA and Canada Health.
Our products are used by NASA for the international space station and planned for proposed interplanetary space missions. Our products have been used in agriculture, food service, households, institutional kitchens, grocery markets, green houses, restaurants, breweries, and military establishments. We strongly support climate control efforts and have reduced pollution by designing concentrated and waterless packaging.
Dr. Lopes has received Albert Nelson Marquis Lifetime Achievement Award and is the author of multiple peer reviewed scientific publications and book editions with chapters in Disinfection, Sterilization and Preservation. The company innovation was recognized by the awards of two national competitive SBIR research grants one from the NIH and the other from the NASA, was nominated by the EPA for the Presidential Green Chemistry Award and has received more than 10 US and Canadian patents for its technology.
Microcide Company PUBLICATIONS:
BOOK Chapters:
Lopes, J.A. 2000. Food- and Water- infective Microorganisms. Chapter 60, In “Disinfection, Sterilization and Preservation” Fifth Edition, Edited by S. S. Block, Lippincott Williams & Wilkins
Lopes, J. A. 1991. Food- and Water- infective Microorganisms. Chapter 45, In “Disinfection, Sterilization and Preservation” Fourth Edition, Edited by S. S. Block, Lea and Febiger.
Dychdala, G. R., and Lopes, J. A. 1991. Surface Active Agents: Acid Anionic Compounds. Chapter 14, In “Disinfection, Sterilization and Preservation” Fourth Edition, Edited by S. S. Block, Lea and Febiger.
Peer Reviewd Publications and Patents
Lopes, J.A. 2001. Concentrated Sanitizing Compositions for Cleaning Food and Food Contact Surfaces. US Patent App. #09/908,527.
Lopes, J.A. 2001. Compositions for Acidic Syndet Bar Soap. US Patent App. # 09/935,930.
Lopes, J.A. 2000. Food- and Water- infective Microorganisms. Chapter 60, In “Disinfection, Sterilization and Preservation” Fifth Edition, Edited by S. S. Block, Lippincott Williams & Wilkins
Lopes, J. A. 1999. Microbicidal and anitizing soap compositions. U.S. Patent #5,942,478.
Lopes, J. A. 1998. Susceptibility of Antibiotic-Resistant and Antibiotic-Sensitive Foodborne Pathogens to Acid Anionic Sanitizers. J. Food Protec.61: 1390-1395.
Lopes, J. A., A. Rillo, and R. J. Lopes. 1998. Effect of Storage Temperature on Population Density of Natural and pathogenic Bacteria on Vegetables. Abstract:P-107. Presented at the Annual meeting of the American Society for Microbiology, Atlanta.
Lopes, J. A. 1994. Inactivation of Giardia cysts by anionic surface-active agent. Presented at the Annual meeting of the American Society for Microbiology, Las Vegas, Abstract #85,May23.
Lopes, J. A. 1994. Disinfecting and sanitizing compositions; U. S. patent # 5,280,042. Jan. 21.
Lopes, J. A. 1992. Microbicidal activity of non-alcoholic mouthwash against four oral anaerobes. Presented at the First North American Congress on Anaerobic Bacteria and Anaerobic Infections. Marina Del Rey, CA.
Lopes, J.A. 1992. Disinfecting and sanitizing compositions; U. S. patent # 5,143,720. Sept. 1.
Microcide PRODUCT Publications– External University
Mendonca, A., Darabă, A. , Manu, D., and Woods,F.: Inactivation of Salmonella enterica on Whole Tomatoes and Serrano Peppers Immersed in PRO-SAN, a Biodegradable Vegetable Sanitizer, Abstracts presented at the Balkan Environmental Association. 2011
Feliciano. L.. Lee. J., Lopes. J., Pascali, M.A. 2010. Efficacy of sanitized ice in reducing bacterial load on fish fillet and in the water collected from the melted ice. Journal Food Science. (Accepted for publication).
Feliciano, L., Pascali, M.A., Lee, J., Lopes, J. 2009. Efficiency of Sanitized Ice in Reducing Bacteriai Load in Whole and Fillet Fish. Presented at 2009 1FT 69th Annual Meeting, Anaheim, CA.
Lee, J., Pascali, M.A., Lopes, J. 2009. Strength of attachment and survivability of bacteria on different fabric materials used to make food handler’s over-coats. Presented at 2009 1FT 69th Annual Meeting, Anaheim, CA.
Lee, J., Pascali, M.A., and Lopes, J. 2008. Efficacy of an acidic sporicidal agent for Bacillus cereus spore reduction on food packaging materials. 2008 1FT 68th Annual Meeting, New Orleans, LA.
Lee, J., Lopes, J. and Pascali, M.A. 2007. Development of a sanitizing fabric wipe for use on food contact surfaces. Journal of Food Science. 72:9. 375-381.
Gupta, M., Lee, J., Pascali, M.A. and Lopes, J. 2007. Comparative efficacies of acidic sanitizers and hydrogen peroxide for food packaging materials. Presented at 2007 1FT 67th Annual Meeting, Chicago, IL.
Lee, J., Lopes, J. and Pascali, M.A. 2007. Development of a sanitizing fabric wipe for use on food contact surfaces. Journal of Food Science. 72:9. 375-381.
Lee, J., Gupta, M., Lopes, J. and Pascali, M.A. 2007. Efficacy of two acidic sanitizers for microbial reduction on metal can and low density polyethylene film surfaces. Journal of Food Science. 72:8. 335-339.
Mendonca, A. F.; Reitmeier,C. A. and Sikinyi, T. Evaluation of a GRAS Sanitizer for Enhanced Microbial Safety and Shelf-life of Whole Tomatoes for ISS and Planetary Outpost. 2004-01-2560, SAE Internationsl 2004.
Early PUBLICATIONS
Stanton, J., Lichorat, J., and Lopes, J. A. 1988. Stable antimicrobial composition containing alkylamine oxide and carboxylic acids. European Patent Appl. 245,928.
Lopes, J. A., and Stanton, J. 1987. Antimicrobial sanitizing composition containing N-alkyl and N-alkenyl succinic acid and methods for use. U. S. Patent 4,715980.
Czechowski, M. H., Rapp, C., Banner, M., and Lopes, J. A. 1987. The use of epifluorescence microscopy in determining Pseudomonas fluorescens attachment to surfaces immersed in a milk solution. Presented at the annual meeting of the Society for Industrial Microbiology, Denver.
Lopes, J. A. 1986. Evaluation of sanitizers against Salmonella typhimurium and Listeria monocytogenes. J. Dairy Sci. 69, 2791-2796.
Lopes, J. A., Weigand, R., and Rothfield, L. 1973. Identification of inducible proteins in outer membranes of gram negative bacteria. American Society for Microbiology, 73rd Annual Meeting.
Lopes, J. A., Nachbar, D., Zucker-Franklin, D., and Silber, R. 1973. Lymphocyte plasma membranes: Analysis of proteins and glycoproteins by SDS-gel electrophoresis. Blood, 41, 131-140.
Lopes, J. A., Zucker-Franklin, D., and Silber, R. 1973. Heterogeneity of 5′-Nucleotidase activity in lymphocytes in chronic lymphocytic leukemia. J. Clin. Invest. 52, 1297-1300.
Lopes, J. A., Gottfried, S., and Rothfield, L. 1972. Leakage of periplasmic enzymes by mutants of Escherichia coli and Salmonella typhimurium: Isolation of “Periplasmic Leaky” mutants. J. Bacteriol., 109, 520-525.
Lopes, J. A., and Inniss, W. E. 1970. Chemical composition of lipopolysaccharide from an avian strain of Escherichia coli 018. Canad. J. Microbiol. 16, 1117-1121.
Lopes, J. A., and Inniss, W. E. 1970. Electron microscopic study of lipopolysaccharide from avian strain of Escherichia coli 018. J. Bacteriol., 103, 238-243.
Lopes, J. A., and Inniss, W. E. 1969. Electron microscopy of effect of polymyxin on Escherichia coli lipopolysaccharide. J. Bacteriol., 100. 1128-1130.
Lopes, J. A. 1969. Composition and fine-structure of lipopolysaccharide from an avian strain of Escherichia coli. Ph.D. Thesis, University of Waterloo.
Lopes, J. A., K. H. Dave , and P. V. Gharpure. 1965 Serological evidence of Coxsackie and ECHO virus infections. Indian J. Med. Sci., 19:509-518.